Short Communication: Diphtheria Toxin Repressor (dtxR) Gene-based Genetic Diversity of Corynebacterium diphtheriae isolated in Jakarta, Indonesia, 2018-2019
نویسندگان
چکیده مقاله:
Background and Objective: In Indonesia, diphtheria cases caused by Corynebacterium diphtheriae are still occurring until today. One of the causes is probably the diphtheria toxin repressor (dtxR) gene which influences toxin expression. Therefore, in this study the characterization of the gene was performed to determine the mutations that affect the DtxR protein. Methods: The dtxR genes of 10 C. diphtheria strains isolated in Jakarta were amplified by conventional PCR. The PCR products were directed to DNA sequencing by using overlapping primers. Results & Conclusion: All the mutations showed no amino acid changes. We proposed that the DtxR protein is conserved among bacterial strains isolated from Jakarta.
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عنوان ژورنال
دوره 17 شماره 2
صفحات 16- 16
تاریخ انتشار 2023-03
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